Cytotoxic Aporphine Alkaloids from Ocotea acutifolia
Fernanda R. Garcez1
, Ana G. Francisca da Silva1,3
, Walmir S. Garcez1
, Gabriela Linck2
, Maria C. de Fatima Matos2
, Evelyn C. S. Santos2
, Lyara M. M. Queiroz2
1Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
2Departamento de Farmácia-Bioquímica, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
3Universidade Estadual de Mato Grosso do Sul, Mundo Novo, MS, Brazil
Two new aporphinoid alkaloids, (+)-6S-ocoteine N-oxide and (+)-norocoxylonine, were isolated from the leaves and trunk bark of Ocotea acutifolia (Lauraceae) along with thirteen aporphine analogues, one morphinan alkaloid, and one flavonoid. The aporphine alkaloids (+)-thalicsimidine and (+)-neolitsine are reported for the first time for the genus Ocotea. The structures of all compounds were established on the basis of 1D- and 2D‐NMR spectroscopic techniques, optical rotation and/or mass spectrometry data. The cytotoxic potential of eight of the aporphine alkaloids against four human cancer cell lines (Hep-2, MCF-7, B16-F10 and 786-0) was also evaluated.
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