Platinum-Catalyzed Asymmetric [3+2] Cycloadditions of Carbonyl Ylides

Significance

Transition-metal-catalyzed cyclo­additions are attractive due to their atom economy and ability to form multiple bonds in a single transformation. Enantioselective variants are particularly useful as multiple stereocenters can be generated from achiral starting materials. Extending on previous racemic work (Angew. Chem. Int. Ed. 2008, 47, 4903), the authors present an enantio­selective platinum(II)-catalyzed domino alkyne activation followed by a [3+2] cycloaddition.