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Synfacts 2010(9): 1089-1089
DOI: 10.1055/s-0030-1257984
DOI: 10.1055/s-0030-1257984
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Aza-Michael Addition in Alkaline Al2O3
X. Ai, X. Wang*, J.-M. Liu, Z.-M. Ge, T.-M. Cheng, R.-T. Li*
Peking University, Beijing, P. R. of China
Further Information
Publication History
Publication Date:
23 August 2010 (online)
Significance
The alkaline Al2O3 mediated aza-Michael addition of aromatic or aliphatic amines (primary or secondary) to electron-deficient alkenes was described. The aza-Michael addition of aniline to acrylonitrile was carried out with alkaline Al2O3 to afford 3-(phenylamino)propionitrile 3a in 98% yield.