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Synfacts 2010(11): 1284-1284
DOI: 10.1055/s-0030-1258705
DOI: 10.1055/s-0030-1258705
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
O-Arylhydroxylamines and Benzofurans via O-Arylation of Ethyl Acetohydroximate
T. J. Maimone, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
Further Information
Publication History
Publication Date:
21 October 2010 (online)
Significance
The bulky ligands t-BuBrettPhos and t-BuXPhos were efficiently used in the palladium-catalyzed O-arylation of ethyl acetohydroximate. The resulting O-arylated products can be converted into the respective arylhydroxylamines or benzofurans.