Ruthenium-Catalyzed Asymmetric Hydrogenation of Bicyclic
Ketones

N. Arai; M. Akashi; S. Sugizaki; H. Ooka; T. Inoue; T. Ohkuma

doi:10.1055/s-0030-1258745

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Synfacts 2010(11): 1262-1262
DOI: 10.1055/s-0030-1258745

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Ruthenium-Catalyzed Asymmetric Hydrogenation of Bicyclic Ketones

Contributor(s): Hisashi Yamamoto, Zhi Li
N. Arai, M. Akashi, S. Sugizaki, H. Ooka, T. Inoue, T. Ohkuma*
Hokkaido University, Sapporo and Nippon Soda Co., Takada, Odawara, Japan

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Publication History

Publication Date:
21 October 2010 (online)

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Significance

Bicyclic ketones are challenging substrates for asymmetric hydrogenation due to their unique structure. In this report, the authors demonstrated that a Ru-BINAP/diamine catalyst system was able to catalyze highly stereoselective hydrogenation of various bicyclic ketones.