Synthesis of 2-Trifluoromethyl
Quinoline by the Reaction of Fluorinated Imine with Alkyne
Catalyzed by Indium(III) Triflate

Haibo Xie; Jiangtao Zhu; Zixian Chen; Shan Li; Yongming Wu

doi:10.1055/s-0030-1258770

LETTER

Synthesis of 2-Trifluoromethyl Quinoline by the Reaction of Fluorinated Imine with Alkyne Catalyzed by Indium(III) Triflate

Haibo Xie^a, Jiangtao Zhu^a, Zixian Chen^a,b, Shan Li^a, Yongming Wu*^a
^a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 LingLing Road, Shanghai 200032, P. R. of China
Fax: +86(21)54925192; e-Mail: ymwu@sioc.ac.cn;
^b Department of Chemistry, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P. R. of China

Abstract

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Abstract

Preparation of 2-trifluoromethyl-4-aryl quinolines from a variety of readily available alkynes and N-aryl trifluoroethylimine has been achieved via indium(III) triflate catalyzed Diels-Alder reactions.

Key words

alkynes - quinolines - indium - Diels-Alder reaction - imines

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References

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