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Synfacts 2011(2): 0122-0122  
DOI: 10.1055/s-0030-1259216
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Pestalone and Pestalalactone

Contributor(s): Steven V. Ley, Philippa B. Cranwell
N. Slavov, J. Cvengroš, J.-M. Neudörfl, H.-G. Schmalz*
Universität zu Köln, Germany
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Publikationsdatum:
19. Januar 2011 (online)

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Significance

Pestalone was isolated in 2001 from a marine fungus of the Pestalotia genus. It exhibits potent activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. In 2008, Che and co-workers isolated racemic metabolites from the plant endophytic fungus Pestalotiopsis adusta, which they called the pestalachlorides.