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Synfacts 2011(2): 0176-0176  
DOI: 10.1055/s-0030-1259264
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rare Earth Metal Catalyzed Asymmetric Intermolecular Hydroamination

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
A. L. Reznichenko, H. P. Nguyen, K. C. Hultzsch*
Rutgers, The State University of New Jersey, Piscataway, USA
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Publikationsdatum:
19. Januar 2011 (online)

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Significance

Catalyst systems for intramolecular hydroamination are well developed; in contrast, the intermolecular hydroamination is difficult to achieve due to the competition between weakly coordinating alkenes and strongly coordinating amines. The authors previously used rare earth metal catalysts in intramolecular hydroamination (J. Am. Chem. Soc. 2006, 128, 3748), and these systems were extended to an intermolecular hydroamination in this report.