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Synfacts 2011(2): 0184-0184  
DOI: 10.1055/s-0030-1259270
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Neodymium-Catalyzed Asymmetric Synthesis of 1,3-Bis(hydroxymethyl)-2-oxindoles

Contributor(s): Hisashi Yamamoto, Jiajing Tan
K. Shen, X. Liu, W. Wang, G. Wang, W. Cao, W. Li, X. Hu, L. Lin, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
19 January 2011 (online)

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Significance

A highly enantioselective hydroxy-methylation of unprotected oxindoles was realized through neodymium-N,N′-dioxide complex to provide useful chiral substituted oxindole derivatives in good yields and excellent enantioselectivities. The desired products were obtained via an unexpected tandem C- and N-addition process.