A Supported Organic Catalyst for Asymmetric Michael Addition

B. G. Wang; B. C. Ma; Q. Wang; W. Wang

doi:10.1055/s-0030-1259373

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Synfacts 2011(2): 0226-0226
DOI: 10.1055/s-0030-1259373

Polymer-Supported Synthesis

A Supported Organic Catalyst for Asymmetric Michael Addition

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Shaheen M. Sarkar
B. G. Wang, B. C. Ma*, Q. Wang, W. Wang*
Lanzhou University, P. R. of China

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Publication History

Publication Date:
19 January 2011 (online)

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Significance

Magnetic nanoparticle (MNP), Fe₃O₄ coated with SiO₂-supported (S)-diphenylprolinol trimethylsilyl ether 7 (Jørgensen-Hayashi catalyst), was prepared and applied to the asymmetric Michael addition. The Michael addition of various aliphatic aldehydes with substituted aromatic nitroalkenes was carried out in water with 7 to give the corresponding adducts in up to 96% yield with 75-90% ee.