Synthesis of (-)-Sclerophytin A

B. Wang; A. P. Ramirez; J. J. Slade; J. P. Morken

doi:10.1055/s-0030-1259638

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Synfacts 2011(4): 0352-0352
DOI: 10.1055/s-0030-1259638

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Sclerophytin A

Contributor(s): Steven V. Ley, James R. Frost
B. Wang, A. P. Ramirez, J. J. Slade, J. P. Morken*
Boston College, Massachusetts, USA

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Publication History

Publication Date:
18 March 2011 (online)

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Significance

Sclerophytin A is an oxygenated cembrane diterpene isolated from the marine soft coral Sclerophytum capitalis. It is cytotoxic against mouse leukemia cells (1 ng/mL versus the L1210 cell line).