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Synfacts 2011(4): 0415-0415  
DOI: 10.1055/s-0030-1259661
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Brønsted Acid Activated Palladium-Catalyzed Hydrogenation of Ketimines

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
X.-Y. Zhou, M. Bao*, Y.-G. Zhou*
Dalian University of Technology and Dalian Institute of Chemical Physics, P. R. of China
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

Asymmetric hydrogenation of im­ines is a well-developed method to prepare chiral amines. The authors extended this methodology to the palladium-catalyzed hydrogenation of ketimines with a Brønsted acid activator.