Synthesis of Diazonamide A

R. R. Knowles; J. Carpenter; S. B. Blakey; A. Kayano; I. K. Mangion; C. J. Sinz; D. W. C. MacMillan

doi:10.1055/s-0030-1259792

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Synfacts 2011(5): 0465-0465
DOI: 10.1055/s-0030-1259792

Synthesis of Natural Products and Potential Drugs

Synthesis of Diazonamide A

Contributor(s): Steven V. Ley, Philippa B. Cranwell
R. R. Knowles, J. Carpenter, S. B. Blakey, A. Kayano, I. K. Mangion, C. J. Sinz, D. W. C. MacMillan*
Princeton University, USA

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Publication History

Publication Date:
15 April 2011 (online)

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Significance

Diazonamide A, a popular synthetic target, was isolated from the colonial marine ascidian Diazonia angulata. It is a potent antimitotic agent and exhibits nanomolar GI₅₀ values towards a range of human cancer cell lines.