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Synfacts 2011(5): 0512-0512
DOI: 10.1055/s-0030-1259832
DOI: 10.1055/s-0030-1259832
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Asymmetric Allylic Alkylation
J.-B. Langlois, A. Alexakis*
University of Geneva, Switzerland
Further Information
Publication History
Publication Date:
15 April 2011 (online)
![](https://www.thieme-connect.de/media/synfacts/201105/lookinside/thumbnails/10.1055-s-0030-1259832-1.jpg)
Significance
The authors describe mechanistic studies on the kinetic resolution of racemic linear allyl chlorides. Following their work on the alkylation of cyclic substrates (Chem. Commun. 2009, 3868), this work reveals a much more complex stereodivergent resolution yielding products as mixtures of E/Z isomers. In addition to the interesting mechanistic insight of this work, the product mixture could be convergently transformed to afford chiral synthons in high yields.