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Synthesis 2011(9): 1383-1398
DOI: 10.1055/s-0030-1259981
DOI: 10.1055/s-0030-1259981
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Benzannulated Spiroketals Using an Oxidative Radical Cyclization
Further Information
Received
20 January 2011
Publication Date:
04 April 2011 (online)
Publication History
Publication Date:
04 April 2011 (online)
Abstract
The synthesis of both mono and bisbenzannulated spiroketals using an oxidative radical cyclization approach is investigated. Although unsuccessful in uncovering a novel route toward bisbenzannulated spiroketals, the oxidative radical cyclization does facilitate a new approach to monobenzannulated spiroketals such as those found in berkelic acid and in the chaetoquadrins.
Key words
spiroketals - berkelic acid - chaetoquadrin - radical cyclization - cross-metathesis
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References
Full details regarding the synthesis of compound 20 will be reported elsewhere.