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Synfacts 2011(8): 0886-0886
DOI: 10.1055/s-0030-1260726
DOI: 10.1055/s-0030-1260726
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Cyanomethylation of Aryl Halides
J. Velcicky*, A. Soicke, R. Steiner, H.-G. Schmalz*
Novartis Institutes for Biomedical Research, Basel, Switzerland and University of Cologne, Germany
Further Information
Publication History
Publication Date:
20 July 2011 (online)
Significance
Herein, an efficient and general protocol for the cyanomethylation of aryl halides and triflates is disclosed. A wide range of electron-donating or electron-accepting functional groups is tolerated on the aryl halide and the desired products are obtained in good yields.