Ruthenium-Catalyzed Regio- and Enantio-selective Allylic
Substitution with Water

N. Kanbayashi; K. Onitsuka

doi:10.1055/s-0030-1260734

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Synfacts 2011(8): 0876-0876
DOI: 10.1055/s-0030-1260734

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Ruthenium-Catalyzed Regio- and Enantio-selective Allylic Substitution with Water

Contributor(s): Mark Lautens, Patrick T. Franke
N. Kanbayashi, K. Onitsuka*
Osaka University, Japan

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Publication History

Publication Date:
20 July 2011 (online)

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Significance

A highly efficient regio- and enantio-selective allylic substitution of monosubstituted allylic chlorides with water has been developed. The products are obtained in excellent enantioselectivities up to 97%.