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Synfacts 2011(8): 0875-0875  
DOI: 10.1055/s-0030-1260741
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Highly Selective Scandium-Catalyzed Aldehyde Crotylation

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
H. Kim, S. Ho, J. Leighton*
Columbia University, New York, USA
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Publication History

Publication Date:
20 July 2011 (online)

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Significance

Though aldehyde crotylation has been extensively studied over the past three decades, severe limitations still inhibit this methodology. In this work, Leighton and co-workers developed a scandium catalyst that gives high enantio- and diastereoselectivities for a much broader scope of aldehydes.