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Synfacts 2011(8): 0854-0854
DOI: 10.1055/s-0030-1260746
DOI: 10.1055/s-0030-1260746
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Iridium-Catalyzed Enantioselective Allylic Dearomatization of Phenols
Q.-F. Wu, W.-B. Liu, C.-X. Zhuo, Z.-Q. Rong, K.-Y. Ye, S.-L. You*
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
20 July 2011 (online)
Significance
In addition to previous research regarding asymmetric dearomatization of phenols (see: Q. Gu, Z.-Q. Rong, C. Zheng, S.-L. You J. Am. Chem. Soc. 2010, 132, 4056), the authors now report an iridium-catalyzed intramolecular allylic dearomatization, which provides a direct access to desired spirocyclohexadienones in good to excellent yields and enantioselectivities.