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Synlett 2011(11): 1597-1601  
DOI: 10.1055/s-0030-1260796
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Zirconyl Chloride: An Efficient, Water-Tolerant, and Reusable Catalyst for the Synthesis of N-Methylamides

Dhrubajyoti Talukdar, Lakhinath Saikia, Ashim Jyoti Thakur*
Department of Chemical Sciences, Tezpur University, Napaam 784028, India
Fax: +91(3712)267005/6; e-Mail: ashim@tezu.ernet.in;
Further Information

Publication History

Received 10 February 2011
Publication Date:
15 June 2011 (online)

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Abstract

ZrOCl2˙8H2O is a highly effective, water-tolerant, and reusable catalyst for the direct condensation of carboxylic acids and N,N′-dimethylurea under microwave irradiation to give the corresponding N-methylamides in moderate to excellent yields. Notably, ZrOCl2˙8H2O is a potentially useful green catalyst due to its low toxicity, easy availability, low cost, ease of handling, easy recovery, good activity, and reusability.

Key words

zirconium oxychloride octahydrate - carboxylic acid - N,N′-dimethylurea - N-methyl amide

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