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Synfacts 2011(10): 1095-1095  
DOI: 10.1055/s-0030-1261062
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Enantioselective Hydroboration

Contributor(s): Hisashi Yamamoto, Susumu Oda
R. Corberán, N. W. Mszar, A. H. Hoveyda*
Boston College, Chestnut Hill, USA
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Publikationsdatum:
20. September 2011 (online)

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Significance

This paper describes the copper-catalyzed enantioselective hydroboration of 1,1-disubstituted aryl alkenes. Despite the recent development of enantioselective hydroboration, utilization of 1,1-disubstitued alkenes remains a challenge. The authors found that the bidentate NHC ligand provided homobenzylic C-B bond formation selectively and attained high enantioselectivity.