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Synfacts 2011(10): 1117-1117  
DOI: 10.1055/s-0030-1261078
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Suzuki Coupling of an Aminomethyl Equivalent with (Hetero)Aryl Halides

Contributor(s): Paul Knochel, Nadja M. Barl
G. A. Molander*, I. Shin
University of Pennsylvania, Philadelphia, USA
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Publication History

Publication Date:
20 September 2011 (online)

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Significance

The one-pot synthesis and the ­Suzuki-Miyaura coupling of potassium Boc-protected aminomethyltrifluoroborate are reported. This synthetic primary aminomethyl equivalent is successfully coupled to electron-rich, -poor and electron-neutral aryl and (hetero)aryl chlorides to provide aminomethyl(hetero)arenes in high yields.