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Synfacts 2011(10): 1144-1144  
DOI: 10.1055/s-0030-1261096
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Henry Reaction with MCM-41-Supported Cu-Salen Complex

Contributor(s): Yasuhiro Uozumi, Aya Tazawa
K. Dhahagani, J. Rajesh, R. Kannan, G. Rajagopal*
Government Arts College, Melur, Madurai Institute of Engineering and Techonology, Sivagangai and, Karunya University, Coimbatore, India
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Publikationsverlauf

Publikationsdatum:
20. September 2011 (online)

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Significance

A novel copper(II)-salen complex supported on MCM-41 [MCM-41-Cu(salen)] was designed, prepared, and characterized by various microscopic and spectroscopic methods. MCM-41-Cu(salen) catalyzed the asymmetric Henry reaction of aldehydes with nitromethane in the presence of morpholine to afford the corresponding ­nitro alcohols in up to 92% yield with up to 90% ee (20 examples, eq. 1).