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Synfacts 2011(10): 1059-1059  
DOI: 10.1055/s-0030-1261105
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Intramolecular Ullmann Cross-Coupling Route to Fused Pyridoquinazolinones

Contributor(s): Victor Snieckus, Johnathan Board
L. Chen, H. Fu*, R. Qiao*
Tsinghua University, Beijing and Beijing University of Chemical Technology, P. R. of China
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Publication History

Publication Date:
20 September 2011 (online)

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Significance

Reported is the synthesis of pyrido-quinazolones using an intramolecular Ullmann-type cross-coupling reaction as the key step. The best yields for the reaction are obtained when aromatic bromides are used as coupling partners, although aromatic chlorides also afford products in somewhat lower yields. This method may be the shortest route to these tricyclic derivatives.