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Synfacts 2011(10): 1128-1128  
DOI: 10.1055/s-0030-1261117
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Organocatalytic Enantioselective Fluorocyclizations

Contributor(s): Benjamin List, Qinggang Wang
O. Lozano, G. Blessley, T. Martinez del Campo, A. L. Thompson, G. T. Giuffredi, M. Bettati, M. Walker, R. Borman, V. Gouverneur*
University of Oxford and GlaxoSmithKline R&D, Stevenage, UK
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Publikationsdatum:
20. September 2011 (online)

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Erratum zu diesem Artikel:

Organocatalytic Enantioselective FluorocyclizationsSynfacts 2011; 2011(11): 1264-1264
DOI: 10.1055/s-0031-1289301

Significance

The first successful catalytic process, which delivers enantioenriched fluorinated heterocyclic products upon fluorocyclization of prochiral precursors has been developed by ­Gouverneur and co-workers. Both mono- and di­fluorinated cyclization products (3 and 4) were obtained under different conditions. According to NMR studies, it is the N-fluoroammonium salt of the alkaloid which may be responsible for the enantiocontrol in the reaction.