Download PDF
Z Gastroenterol 2012; 50(02): 226-231
DOI: 10.1055/s-0031-1281967
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Biliary Papillomatosis and New Ultrasound Imaging Modalities

Biliäre Papillomatose und neue sonografische Techniken
X. W. Cui
1   Caritas-Krankenhaus Bad Mergentheim, Bad Mergentheim, Germany
,
A. Ignee
1   Caritas-Krankenhaus Bad Mergentheim, Bad Mergentheim, Germany
,
B. Braden
2   Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, U.K.
,
M. Woenckhaus
1   Caritas-Krankenhaus Bad Mergentheim, Bad Mergentheim, Germany
,
C. F. Dietrich
1   Caritas-Krankenhaus Bad Mergentheim, Bad Mergentheim, Germany
› Author Affiliations
Further Information

Publication History

08 August 2011

04 November 2011

Publication Date:
01 February 2012 (online)

Also available at
    Permissions and Reprints

Abstract

Biliary papillomatosis (BP) is a rare disorder of the biliary tract with a significant risk of malignant transformation and a high recurrence rate after operation due to the diffuse distribution of the disease. Preoperative diagnosis is difficult also by reason of the low sensitivity and specificity of conventional ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), endoscopic retrograde cholangiography (ERC) and positron emission tomography (PET). Therefore, the introduction of new diagnostic imaging methods is of importance to improve the preoperative diagnosis of this originally as benign described disease which is reflected in the term of “benign papillomatosis of the biliary tree”. The present review summarizes the literature and discusses new sonographic imaging techniques including contrast-enhanced ultrasound (CEUS), contrast-enhanced low mechanical endoscopic ultrasound (CELMI-EUS) and endoscopic ultrasound elastography.

Zusammenfassung

Die biliäre Papillomatose ist eine selten diagnostizierte Erkrankung der Gallenwege, die mit dem Risiko einer malignen Transformation behaftet ist. Die präoperative Diagnose ist schwierig, da die Veränderungen mittels konventioneller Ultraschalltechnik, Computertomografie, Magnetresonanztomografie und endoskopischer retrograder Cholangiografie unspezifisch sind und wegweisende Befunde selten erhoben werden. Durch die Einführung neuer bildgebender Methoden, wie die kontrastverstärkte Sonografie, kontrastverstärkte Endosonografie und Elastografie erscheint es möglich, neoplastisches Gewebe von Sludge, Schleim und nicht verkalkten Konkrementen zu differenzieren. Die Elastografie ermöglicht insbesondere die Wandanalyse und kann somit frühzeitige Wandinfiltrationen des härteren Tumorgewebes im Vergleich zur relativ weicheren Wand dokumentieren. Neben der Einführung und Diskussion dieser neuen bildgebenden Methoden erfolgt ein Literaturreview.

Key words

biliary papillomatosis - cholangiocellular adenoma - cholangiocellular carcinoma - contrast-enhanced ultrasound - endoscopic ultrasound - elastography

Schlüsselwörter

biliäre Papillomatose - cholangiozelluläres Karzinom - cholangiozelluläres Adenom - Cholezystolithiasis - kontrastverstärkter Ultraschall - endoskopischer Ultraschall - Elastografie
 

  • References

  • 1 Braeye L, Vanheste R. Biliary papillomatosis. Hepatology 2010; 52: 1512-1514
    CrossrefPubMedGoogle Scholar
  • 2 Yeung YP, AhChong K, Chung CK et al. Biliary papillomatosis: report of seven cases and review of English literature. J Hepatobiliary Pancreat Surg 2003; 10: 390-395
    CrossrefPubMedGoogle Scholar
  • 3 Lee SS, Kim MH, Lee SK et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer 2004; 100: 783-793
    CrossrefPubMedGoogle Scholar
  • 4 Donnellan F, Swan MP, May GR et al. Biliary papillomatosis diagnosed with mother-daughter narrow-band imaging (NBI) cholangioscopy. Endoscopy 2011; 43 (Suppl. 02) E86-E87
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Ma KF, Iu PP, Chau LF et al. Clinical and radiological features of biliary papillomatosis. Australas Radiol 2000; 44: 169-173
    CrossrefPubMedGoogle Scholar
  • 6 Dietrich CF, Kratzer W, Strobe D et al. Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI. World J Gastroenterol 2006; 12: 1699-1705
    CrossrefPubMedGoogle Scholar
  • 7 Correas JM, Tranquart F, Claudon M. Guidelines for contrast enhanced ultrasound (CEUS) – update 2008. J Radiol 2009; 90 (01) 123-138
    CrossrefPubMedGoogle Scholar
  • 8 Xu HX. Contrast-enhanced ultrasound in the biliary system: Potential uses and indications. World J Radiol 2009; 1: 37-44
    CrossrefPubMedGoogle Scholar
  • 9 Xu HX, Chen LD. Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings. J Clin Ultrasound 2008; 36: 39-41
    CrossrefPubMedGoogle Scholar
  • 10 Lai R, Freeman ML, Mallery S. EUS in multiple biliary papillomatosis. Gastrointest Endosc 2002; 55: 121-125
    CrossrefPubMedGoogle Scholar
  • 11 Seifert H, Wehrmann T, Hilgers R et al. Catheter probe extraductal EUS reliably detects distal common bile duct abnormalities. Gastrointest Endosc 2004; 60: 61-67
    CrossrefPubMedGoogle Scholar
  • 12 Dietrich CF, Ignee A, Braden B et al. Improved differentiation of pancreatic tumors using contrast-enhanced endoscopic ultrasound. Clin Gastroenterol Hepatol 2008; 6: 590-597
    CrossrefPubMedGoogle Scholar
  • 13 Hocke M, Schulze E, Gottschalk P et al. Contrast-enhanced endoscopic ultrasound in discrimination between focal pancreatitis and pancreatic cancer. World J Gastroenterol 2006; 12: 246-250
    CrossrefPubMedGoogle Scholar
  • 14 Kitano M, Kudo M, Sakamoto H et al. Endoscopic ultrasonography and contrast-enhanced endoscopic ultrasonography. Pancreatology 2011; 11 (Suppl. 02) 28-33
    CrossrefPubMedGoogle Scholar
  • 15 Dietrich CF, Hirche TO, Ott M et al. Real-time tissue elastography in the diagnosis of autoimmune pancreatitis. Endoscopy 2009; 41: 718-720
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Hirche TO, Ignee A, Barreiros AP et al. Indications and limitations of endoscopic ultrasound elastography for evaluation of focal pancreatic lesions. Endoscopy 2008; 40: 910-917
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Chappet V. Cancerepithelial primitif du canal choljdoque. Lyon Med 1894; 76: 145
    PubMedGoogle Scholar
  • 18 Ohtsubo K, Ohta H, Sakai J et al. Mucin-producing biliary papillomatosis associated with gastrobiliary fistula. J Gastroenterol 1999; 34: 141-144
    CrossrefPubMedGoogle Scholar
  • 19 Amaya S, Sasaki M, Watanabe Y et al. Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis. Histopathology 2001; 38: 550-560
    CrossrefPubMedGoogle Scholar
  • 20 Kim JD, Lee KM, Chung WC et al. Acute pancreatitis and cholangitis caused by hemobilia from biliary papillomatosis. Gastrointest Endosc 2007; 65: 177-180
    CrossrefPubMedGoogle Scholar
  • 21 Mukai H, Yasuda K, Nakajima M. Tumors of the papilla and distal common bile duct. Diagnosis and staging by endoscopic ultrasonography. Gastrointest Endosc Clin N Am 1995; 5: 763-772
    PubMedGoogle Scholar
  • 22 Snady H, Cooperman A, Siegel J. Endoscopic ultrasonography compared with computed tomography with ERCP in patients with obstructive jaundice or small peri-pancreatic mass. Gastrointest Endosc 1992; 38: 27-34
    CrossrefPubMedGoogle Scholar
  • 23 Albrecht T, Blomley M, Bolondi L et al. Guidelines for the use of contrast agents in ultrasound. Ultraschall in Med 2004; 25: 249-256
    Article in Thieme ConnectPubMedGoogle Scholar
  • 24 Claudon M, Cosgrove D, Albrecht T et al. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) – update 2008. Ultraschall in Med 2008; 29: 28-44
    Article in Thieme ConnectPubMedGoogle Scholar
  • 25 Itoh T, Hirooka Y, Itoh A et al. Usefulness of contrast-enhanced transabdominal ultrasonography in the diagnosis of intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol 2005; 100: 144-152
    CrossrefPubMedGoogle Scholar
  • 26 Dietrich CF, Ignee A, Frey H. Contrast-enhanced endoscopic ultrasound with low mechanical index: a new technique. Z Gastroenterol 2005; 43: 1219-1223
    Article in Thieme ConnectPubMedGoogle Scholar
  • 27 Dietrich CF. Contrast-enhanced low mechanical index endoscopic ultrasound (CELMI-EUS). Endoscopy 2009; 41 (Suppl. 02) E43-E44
    Article in Thieme ConnectPubMedGoogle Scholar
  • 28 Saftoiu A, Vilmann P, Gorunescu F et al. Accuracy of endoscopic ultrasound elastography used for differential diagnosis of focal pancreatic masses: a multicenter study. Endoscopy 2011; 43: 596-603
    Article in Thieme ConnectPubMedGoogle Scholar
  • 29 Imvrios G, Papanikolaou V, Lalountas M et al. Papillomatosis of intra- and extrahepatic biliary tree: Successful treatment with liver transplantation. Liver Transpl 2007; 13: 1045-1048
    CrossrefPubMedGoogle Scholar
  • 30 Dumortier J, Scoazec JY, Valette PJ et al. Successful liver transplantation for diffuse biliary papillomatosis. J Hepatol 2001; 35: 542-543
    CrossrefPubMedGoogle Scholar
  • 31 Beavers KL, Fried MW, Johnson MW et al. Orthotopic liver transplantation for biliary papillomatosis. Liver Transpl 2001; 7: 264-266
    CrossrefPubMedGoogle Scholar
  • 32 D'Abrigeon G, Blanc P, Bauret P et al. Diagnostic and therapeutic aspects of endoscopic retrograde cholangiography in papillomatosis of the bile ducts: analysis of five cases. Gastrointest Endosc 1997; 46: 237-243
    CrossrefPubMedGoogle Scholar
  • 33 Baughman SM, Bishoff JT, Zimmerman MK et al. Case report: serial percutaneous cholangioscopy with laser ablation for the management of locally recurrent biliary intraductal papillary mucinous tumor. J Gastrointest Surg 2005; 9: 215-218
    CrossrefPubMedGoogle Scholar
  • 34 Jazrawi SF, Nguyen D, Barnett C et al. Novel application of intraductal argon plasma coagulation in biliary papillomatosis (with video). Gastrointest Endosc 2009; 69: 372-374
    CrossrefPubMedGoogle Scholar
  • 35 Gunven P, Gorsetman J, Ohlsen H et al. Six-year recurrence free survival after intraluminal iridium-192 therapy of human bilobar biliary papillomatosis. A case report. Cancer 2000; 89: 69-73
    PubMedGoogle Scholar
  • 36 Dietrich CF, Seifert H, Schreiber-Dietrich D et al. Benigne Papillomatose der Gallenwege: Eine sonographische Blickdiagnose?. Ultraschall in Med 1998; 19: S88
    PubMedGoogle Scholar