Download PDF
Synfacts 2011(11): 1213-1213  
DOI: 10.1055/s-0031-1289181
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Phosphorus Amidite-Olefin Ligands for Allylic Alkylation of Indoles

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
Z. Liu, Z. Cao, H. Du*
Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. of China
Further Information

Publication History

Publication Date:
19 October 2011 (online)

   Buy Article Permissions and Reprints
Zoom Image

Significance

Optically active indoles, which are commonly found in biologically and medicinally important compounds, are often synthesized through allylic alkylation. The authors here developed a novel phosphorus amidite-olefin ligand for the palladium-catalyzed asymmetric alkylation of indoles.