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Synfacts 2011(11): 1259-1259
DOI: 10.1055/s-0031-1289241
DOI: 10.1055/s-0031-1289241
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper Nanoparticles on Activated Carbon for Click Chemistry
F. Alonso*, Y. Moglie, G. Radivoy, M. Yus*
Universidad de Alicante, Spain and Universidad Nacional del Sur, Bahìa Blanca, Argentina
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Oktober 2011 (online)
Significance
Copper nanoparticles (CuNPs) were prepared on activated carbon by mixing CuCl2, lithium metal, and a catalytic amount (10 mol%) of 4,4′-di-tert-butylbiphenyl. The CuNPs-catalyzed (0.5 mol% Cu) Huisgen cycloaddition (click reaction) of alkyl, alkenyl, and benzylic halides/diazonium with sodium azide and terminal alkynes were carried out in water at 70 ˚C to give the corresponding triazoles 1 and 2 in up to 99% yields. Aromatic amines also gave the corresponding triazoles 3 in the presence of t-BuONO.
