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Synfacts 2011(11): 1258-1258  
DOI: 10.1055/s-0031-1289242
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles with Silica-Bonded PPSA

Contributor(s): Yasuhiro Uozumi, Haifeng Zhou
K. Niknam*, A. Deris, F. Naeimi, F. Majleci
Persian Gulf University, Bushehr, Iran
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Publication History

Publication Date:
19 October 2011 (online)

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Significance

Silica-bonded propylpiperazine-N-sulfamic acid (SBPPSA) was prepared according to eq. 1. SBPPSA catalyzed the four-component condensation of benzil, aromatic aldehydes, primary amines, and ammonium acetate under solvent-free conditions to give the corresponding 1,2,4,5-tetrasubstituted imidazoles 1 in 70-92% yield (eq. 2, 19 examples).