Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2011(11): 1252-1252
DOI: 10.1055/s-0031-1289247
DOI: 10.1055/s-0031-1289247
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Denitrogenative Deuteration of Solid-Supported Triazenes
S. Vanderheiden, B. Bulat, T. Zevaco, N. Jung*, S. Bräse*
Karlsruher Institut für Technologie, Karlsruhe and Eggenstein-Leopoldshafen, Germany
Further Information
Publication History
Publication Date:
19 October 2011 (online)

Significance
The solid-phase synthesis of deuterated arenes was described. Substituted anilines were converted into the immobilized triazenes through diazotization followed by the treatment with benzylamine resin. Thermal decomposition of the supported triazenes afforded the corresponding mono-deuterated and methoxy-d 3 arenes in the presence of trifluoroacetic acid-d (TFA-d)-THF-d 8 (method A), TFA-d-methanol-d 4 (method B), and TFA-methanol-d 4 (method C), respectively.