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Synfacts 2011(12): 1277-1277  
DOI: 10.1055/s-0031-1289318
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a Renin Inhibitor

Contributor(s): Philip Kocienski
L.-C. Campeau*, S. J. Dolman, D. Gauvreau, E. Corley, J. Liu, E. N. Guidry, S. G. Ouellet, D. Steinhuebel, M. Weisel, P. D. O’Shea
Merck-Frosst, Kirkland, Canada; Merck, Rahway, USA
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The target molecule is a renin inhibitor that was a candidate for the treatment of hypertension. The multikilogram-scale synthesis ­depicted (15% overall yield) features an efficient asymmetric hydrogenation (F → G) as a key step.