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Synfacts 2011(12): 1278-1278
DOI: 10.1055/s-0031-1289340
DOI: 10.1055/s-0031-1289340
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (+)-Grandisine D
J. D. Cuthbertson, A. A. Godfrey, R. J. K. Taylor*
University of York, Heslington and AstraZeneca, Macclesfield, UK
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
(+)-Grandisine B and D were isolated from the tree Elaeocarpus grandis, located in the Australian rainforest. These indolizine alkaloids display human δ-opioid receptor affinity and as such have gained considerable attention from the synthetic community, resulting in several total syntheses.