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Synfacts 2011(12): 1326-1326  
DOI: 10.1055/s-0031-1289362
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Intramolecular Benzylic C-H Bond Amination

Contributor(s): Mark Lautens, Patrick T. Franke
M. Ichinose, H. Suematsu, Y. Yasutomi, Y. Nishioka, T. Uchida, T. Katsuki*
Kyushu University, Fukuoka, Japan
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Publikationsdatum:
18. November 2011 (online)

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Significance

Iridium(III)-salen complexes are employed as efficient catalysts for the enantioselective intramolecular C-H bond amination. This report constitutes the first highly enantioselective intramolecular C-H bond amination with azide compounds as nitrenoid precursors. The general reaction scale for this transformation is 0.3 mmol.