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Synfacts 2011(12): 1383-1383
DOI: 10.1055/s-0031-1289419
DOI: 10.1055/s-0031-1289419
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Suzuki Coupling of Alkynyl Bromides with Boronic Acids by Pd-SiO2@Fe3O4
X. Zhang, P. Li, Y. Ji, L. Zhang, L. Wang*
Anhui Agricultural University, Shanghai Institute of Organic Chemistry and Huaibei Normal University, Anhui, P. R. of China
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
A magnetic nanoparticle-supported palladium complex (Pd-SiO2@Fe3O4) was prepared by anchoring a silylalkylphosphine onto silica-coated Fe3O4 followed by treatment with Pd(OAc)2 (eq. 1). Pd-SiO2@Fe3O4 catalyzed the Suzuki coupling of alkynyl bromides 2 with organoboronic acids 1 to give the corresponding coupling products 3 in 73-98% yield (21 examples, eq. 2).