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Synlett 2011(20): 3002-3004
DOI: 10.1055/s-0031-1289898
DOI: 10.1055/s-0031-1289898
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of the C1-C13 Fragment of Biselyngbyaside
Further Information
Received
16 September 2011
Publication Date:
23 November 2011 (online)
Publication History
Publication Date:
23 November 2011 (online)
Abstract
An advanced intermediate vinyl iodide corresponding to the C1-C13 fragment of the macrolide biselyngbyaside was prepared by a cross-metathesis reaction between vinyl alcohol and alkene building blocks. The latter fragment, containing two stereocenters, was obtained by employing an asymmetric alkylation, a Wittig reaction, a hydrozirconation, and a Brown allylation as key steps.
Key words
natural products - Brown allylation - cross-metathesis - 1,5-diols - hydrozirconation
- Supporting Information for this article is available online:
- Supporting Information
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