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Synlett 2012; 23(11): 1590-1604
DOI: 10.1055/s-0031-1290984
DOI: 10.1055/s-0031-1290984
account
Conjugate Additions to Vinyl-Substituted Aromatic N-Heterocycles
Further Information
Publication History
Received: 23 December 2011
Accepted after revision: 27 February 2012
Publication Date:
11 June 2012 (online)
Dedicated to Professor Walter S. Trahanovksy on the occasion of his 70th birthday
Abstract
Conjugate or Michael addition to vinyl-substituted aromatic N-heterocycles has been a useful synthetic method for the synthesis of functionalized heterocyclic compounds. A wide variety of heterocycles and nucleophiles undergo this chemistry. Recent work in this area has utilized transition-metal catalysts and some asymmetric synthesis has been accomplished. An overview of this chemistry is presented in this account.
1 Introduction
2 General Aspects
3 Carbon-Centered Nucleophiles
4 Nitrogen-Centered Nucleophile
5 Oxygen and Sulfur Nucleophiles
6 Transition-Metal-Catalyzed Reactions
7 Asymmetric Conjugate Addition
8 Summary and Outlook
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