Copper on Iron: Catalyst and Scavenger for Azide–Alkyne Cycloaddition

Szabolcs Kovács; Katalin Zih-Perényi; Ádám Révész; Zoltán Novák

doi:10.1055/s-0032-1317697

Synthesis, Inhaltsverzeichnis

Synthesis 2012; 44(24): 3722-3730
DOI: 10.1055/s-0032-1317697

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Copper on Iron: Catalyst and Scavenger for Azide–Alkyne Cycloaddition

Szabolcs Kovács

^aInstitute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary

,

Katalin Zih-Perényi

^aInstitute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary

,

Ádám Révész

^bDepartment of Materials Physics, Institute of Physics, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary Fax: +36(1)3722909 eMail: novakz@elte.hu

,

Zoltán Novák*

^aInstitute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary

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Abstract

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Abstract

Dipolar cycloaddition of terminal alkynes and azides catalyzed by the Cu/Fe bimetallic system is reported. In the presence of a readily accessible nanosized copper source, the cycloaddition reaction can be easily achieved at ambient temperature with high efficiency. The product obtained from the reaction catalyzed by Cu/Fe contains significantly lower copper contaminants compared to various active homogeneous copper complexes. Iron not only behaves as support for copper, but acts as a redox scavenger, and reduces the copper contamination of the organic product.

Key words

alkynes - azides - copper - iron - supported catalysis

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Referenzen

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Zusatzmaterial

Supporting Information