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Synthesis 2012; 44(24): 3722-3730
DOI: 10.1055/s-0032-1317697
DOI: 10.1055/s-0032-1317697
feature article
Copper on Iron: Catalyst and Scavenger for Azide–Alkyne Cycloaddition
Further Information
Publication History
Received: 14 September 2012
Accepted after revision: 31 October 2012
Publication Date:
20 November 2012 (online)
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Abstract
Dipolar cycloaddition of terminal alkynes and azides catalyzed by the Cu/Fe bimetallic system is reported. In the presence of a readily accessible nanosized copper source, the cycloaddition reaction can be easily achieved at ambient temperature with high efficiency. The product obtained from the reaction catalyzed by Cu/Fe contains significantly lower copper contaminants compared to various active homogeneous copper complexes. Iron not only behaves as support for copper, but acts as a redox scavenger, and reduces the copper contamination of the organic product.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information