Synthesis 2012; 44(24): 3722-3730
DOI: 10.1055/s-0032-1317697
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© Georg Thieme Verlag Stuttgart · New York

Copper on Iron: Catalyst and Scavenger for Azide–Alkyne Cycloaddition

Szabolcs Kovács
a   Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary
,
Katalin Zih-Perényi
a   Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary
,
Ádám Révész
b   Department of Materials Physics, Institute of Physics, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary    Fax: +36(1)3722909   Email: novakz@elte.hu
,
Zoltán Novák*
a   Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary
› Author Affiliations
Further Information

Publication History

Received: 14 September 2012

Accepted after revision: 31 October 2012

Publication Date:
20 November 2012 (online)


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Abstract

Dipolar cycloaddition of terminal alkynes and azides catalyzed by the Cu/Fe bimetallic system is reported. In the presence of a readily accessible nanosized copper source, the cycloaddition reaction can be easily achieved at ambient temperature with high efficiency. The product obtained from the reaction catalyzed by Cu/Fe contains significantly lower copper contaminants compared to various active homogeneous copper complexes. Iron not only behaves as support for copper, but acts as a redox scavenger, and reduces the copper contamination of the organic product.

Supporting Information