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Synfacts 2013; 9(1): 0090
DOI: 10.1055/s-0032-1317742
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Fluorination of Nickel(II)–Aryl Complexes with [18F]Fluoride

Contributor(s):
Paul Knochel
,
Andreas K. Steib
Lee E, Hooker JM, Ritter T * Harvard University, Cambridge, General Hospital and Harvard Medical School, Charlestown and Massachusetts General Hospital, Boston, USA
Nickel-Mediated Oxidative Fluorination for PET with Aqueous [18F]Fluoride.

J. Am. Chem. Soc. 2012;
134: 17456-17458
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Further Information

Publication History

Publication Date:
17 December 2012 (online)

 
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Key words

nickel - fluorination - palladium

Significance

The authors report a one-step oxidative fluorination of arylnickel complexes which enables a straight-forward and practical 18F late-stage fluorination of molecules. Therefore, 18F-labeled substances of high specific activity for PET imaging can be synthesized.


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Comment

As the protocol can be performed using aqueous fluoride solutions, extensive drying procedures of fluoride, which are typical for radiochemistry, are not required. Furthermore, direct use of aqueous fluoride solutions increases the yield and prevents radioactive decay.


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