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Synthesis 2013; 45(7): 971-977
DOI: 10.1055/s-0032-1318273
DOI: 10.1055/s-0032-1318273
paper
Recyclization in the Series of Spiro[indole-3,5′-pyrimido[4,5-b]quinoline]-2,2′,4′-triones Prepared by a Three-Component Reaction of Isatins with (Thio)barbituric Acids and Electron-Rich Anilines
Further Information
Publication History
Received: 10 December 2012
Accepted after revision: 30 January 2013
Publication Date:
14 February 2013 (online)
Abstract
A ring–ring transformation in the series of spiro[indole-3,5′-pyrimido[4,5-b]quinoline]-2,2′,4′-trione derivatives prepared by a three-component reaction of (thio)barbituric acids, electron-rich aromatic amines, and isatins was observed.
Key words
multicomponent reaction - barbituric acids - aromatic amines - isatins - spiro[indole-3,5′-pyrimido[4,5-b]quinoline]-2,2′,4′-triones - recyclizationSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis. Included are experimental procedures, characterization data, and 1H, 13C NMR spectra of all compounds.
- Supporting Information
-
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