A Biomimetic Approach to Terpenes Isolated from Marine Sponges: a Ugi Coupling Reaction in a Hypothetical Biosynthesis

Abstract

A unique pathway for the biosynthesis of marine sponge terpenes is proposed. Based on this proposal, a biomimetic approach using a Ugi coupling reaction has been designed and applied to the efficient construction of the right-side, peptide-like portions of boneratamides and exigurin.

Key words

Ugi reaction - biomimetic synthesis - terpenes - marine sponges - ugiase

• References

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