Microwave-Assisted Synthesis of 4-Substituted 2-Methylthiopyrimidines

Abstract

Typically, S_NAr reactions at 4-chloro-2-methylthiopyrimidine are carried out employing DMF and sodium hydride under inert gas as well as prolonged reaction times. Herein, we describe a mild and rapid microwave-assisted synthesis to achieve 4-substituted 2-methylthiopyrimidnes from the corresponding chlorine precursor. Moderate to excellent yields were obtained in a green chemistry fashion requiring only few minutes of reaction time.

Key words

green chemistry - pyrimidine - combinatorial chemistry - medicinal chemistry - nucleophilic aromatic substitution

• References

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