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Horm Metab Res 2013; 45(10): 736-740
DOI: 10.1055/s-0033-1345118
Original Basic
© Georg Thieme Verlag KG Stuttgart · New York

Insulin Resistance Induced by Zymosan as a New Animal Model in Mice

L.-Y. Wang   #
1   Department of Pediatrics, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan
2   The Center of General Education, Chia Nan University of Pharmacy & Science, Rende, Tainan City, Taiwan
,
P.-M. Ku   #
3   Department of Cardiology, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan
,
S.-H. Chen
4   Department of Obstetrics and Gynecology, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan
5   Department of Medical Research, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan
,
H.-H. Chung
6   Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
,
Y.-M. Yu
7   Department of Nutrition and Institute of Medical Science, College of Health Science, Chang Jung Christian University, Guei-Ren, Tainan City, Taiwan
,
J.-T. Cheng
5   Department of Medical Research, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan
7   Department of Nutrition and Institute of Medical Science, College of Health Science, Chang Jung Christian University, Guei-Ren, Tainan City, Taiwan
› Author Affiliations
Further Information

Publication History

received 04 March 2013

accepted 09 April 2013

Publication Date:
16 July 2013 (online)

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Abstract

Insulin resistance (IR) is known as a main problem in diabetic disorders. Some animal models for research in IR have been mentioned. Each model shows merit with some disadvantages. Thus, a new animal model for IR is required. The present study used zymosan, a mixture of cell-wall particles from the yeast named Saccharomyces cerevisiae, to establish a new model of IR in mice. Also, we compared the difference of this model with fructose-rich chow-induced model and found some merits of this model. Moreover, we identified that this model induced by zymosan is reversible and IR can be reversed gradually after termination of treatment. Taken together, we suggest zymosan as a useful agent to induce IR through inflammatory pathway in mice.

Key words

insulin resistance - zymosan - fructose-rich chow - western blot - mice

# The first and second author contributed equally to the article.


 

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