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DOI: 10.1055/s-0034-1378533
Synthesis and Application of N-Heterocyclic Carbene–Palladium Ligands with Glycerol Dendrons for the Suzuki–Miyaura Cross-Coupling in Water
Publikationsverlauf
Received: 09. Mai 2014
Accepted after revision: 25. Juni 2014
Publikationsdatum:
11. August 2014 (online)


Abstract
Highly active glycerol-dendron-supported N-heterocyclic carbene–palladium catalysts with catalytic sites at the core position were obtained with an efficient modular synthesis. A symmetrical ligand structure was designed to build a larger microenvironment by increasing the number of dendron generations. The catalytic activity was tested in Suzuki–Miyaura cross-coupling reactions. Deprotection of the dendritic supported catalysts allowed the catalytic reaction to take place in neat water, which is highly desirable for a more sustainable processing. A positive dendritic effect was observed for coupling of activated and nonactivated bromoaryls.
Key words
supported catalysis - dendrimers - carbene complexes - palladium - cross-coupling - green chemistrySupporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information