Synlett 2014; 25(15): 2161-2165
DOI: 10.1055/s-0034-1378533
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis and Application of N-Heterocyclic Carbene–Palladium Ligands with Glycerol Dendrons for the Suzuki–Miyaura Cross-Coupling in Water

Maike C. Lukowiak
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany   Fax: +49(30)83853357   eMail: haag@chemie.fu-berlin.de
,
Markus Meise
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany   Fax: +49(30)83853357   eMail: haag@chemie.fu-berlin.de
,
Rainer Haag*
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany   Fax: +49(30)83853357   eMail: haag@chemie.fu-berlin.de
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Received: 09. Mai 2014

Accepted after revision: 25. Juni 2014

Publikationsdatum:
11. August 2014 (online)


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Abstract

Highly active glycerol-dendron-supported N-heterocyclic carbene–palladium catalysts with catalytic sites at the core position were obtained with an efficient modular synthesis. A symmetrical ligand structure was designed to build a larger microenvironment by increasing the number of dendron generations. The catalytic activity was tested in Suzuki–Miyaura cross-coupling reactions. Deprotection of the dendritic supported catalysts allowed the catalytic reaction to take place in neat water, which is highly desirable for a more sustainable processing. A positive dendritic effect was observed for coupling of activated and nonactivated bromoaryls.

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