Organocatalytic Strategies for the Synthesis of Axially Chiral Compounds

Giorgio Bencivenni

doi:10.1055/s-0034-1378712

Synlett, Inhaltsverzeichnis

Synlett 2015; 26(14): 1915-1922
DOI: 10.1055/s-0034-1378712

synpacts

Organocatalytic Strategies for the Synthesis of Axially Chiral Compounds

Autoren

Giorgio Bencivenni*

Department of Industrial Chemistry ‘Toso Montanari’', School of Science, University of Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy eMail: giorgio.bencivenni2@unibo.it

Abstract

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Abstract

Atropisomers are compounds in which chirality arises from hindered rotation along the carbon–carbon or carbon–heteroatom single bond. Recently, organocatalysis appeared to be a rapid, valuable, and efficient strategy for their preparation in an enantioselective manner. In this report a general overview of the most important organocatalyzed atroposelective transformations will be given pointing out in particular the specific role played by the catalyst.

1 Dynamic Kinetic Resolution

2 Desymmetrization of Biaryls

3 Direct Synthesis of Biaryls

4 Asymmetric Friedel–Crafts Amination of Naphthols

5 N-Alkylation via Phase-Transfer Catalysis

6 Desymmetrization of N-Arylmaleimides

Key words

atropisomers - organocatalysis - enantioselective synthesis - desymmetrization - dynamic kinetic resolution

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Referenzen

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