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DOI: 10.1055/s-0034-1378838
Iridium-Stabilized π-Selenocyclohexadienyls: Synthesis, Molecular Structure, and Cytotoxicity
Publication History
Received: 18 March 2015
Accepted after revision: 29 May 2015
Publication Date:
15 June 2015 (online)
Dedicated to Professor K. Peter C. Vollhardt on the occasion of his 69th birthday
Abstract
A series of iridium-stabilized selenocyclohexadienyls of general formula [Cp*Ir(η5-C6H5–nMenSe)][BF4] {Cp* = η5-C5Me5, n = 0, n = 1, and n = 3} is described, with the selenocyclohexadienyl unit being isolated for the first time by π-coordination to a Cp*Ir moiety. The solid-state structure of one of [Cp*Ir(η5-C6H2Me3Se)][BF4] was determined by single-crystal X-ray diffraction analysis. These compounds are obtained in good yields as orange-red microcrystalline solids by halogen displacement from the related π-bonded arene-chlorinated starting materials using Na2Se as the selenium source. Furthermore, these new compounds display relevant cytotoxic properties towards human ovarian cancer cells.
Key words
selenocyclohexadienyls - iridium-stabilized intermediates - π-complexes - X-ray crystal structureSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1378838.
- Supporting Information
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References and Notes
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