Synlett 2015; 26(04): 461-466
DOI: 10.1055/s-0034-1378938
letter
© Georg Thieme Verlag Stuttgart · New York

Click To Bind: Microwave-Assisted Solid-Phase Synthesis of Peptoids Incorporating Pyridine–Triazole Ligands and Their Copper(II) Complexes

Tamar Zabrodski
Schulich Faculty of Chemistry, Technion – Israel Institute of Technology, Haifa, 3200008, Israel   Fax: +972(4)8293947   eMail: gm92@tx.technion.ac.il
,
Maria Baskin
Schulich Faculty of Chemistry, Technion – Israel Institute of Technology, Haifa, 3200008, Israel   Fax: +972(4)8293947   eMail: gm92@tx.technion.ac.il
,
Prathap Jeya Kaniraj
Schulich Faculty of Chemistry, Technion – Israel Institute of Technology, Haifa, 3200008, Israel   Fax: +972(4)8293947   eMail: gm92@tx.technion.ac.il
,
Galia Maayan*
Schulich Faculty of Chemistry, Technion – Israel Institute of Technology, Haifa, 3200008, Israel   Fax: +972(4)8293947   eMail: gm92@tx.technion.ac.il
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Publikationsverlauf

Received: 08. September 2014

Accepted after revision: 20. Oktober 2014

Publikationsdatum:
21. November 2014 (online)


Abstract

We describe a fast and efficient incorporation of the ligands 2-(1H-1,2,3-triazol-4-yl)pyridine and 2-(1H-1,2,3-triazol-1-ylmethyl)-pyridine into N-substituted glycine peptoid oligomers by the azide–alkyne cycloaddition (click) reaction on a solid support under microwave irradiation. Peptoids bearing these ligands formed stable complexes with copper(II).

Supporting Information

 
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