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Synlett 2014; 25(18): 2654-2660
DOI: 10.1055/s-0034-1379182
DOI: 10.1055/s-0034-1379182
letter
Diastereoselective Synthesis of Methanopyridoxazocinones
Further Information
Publication History
Received: 12 June 2014
Accepted after revision: 29 August 2014
Publication Date:
07 October 2014 (online)
Abstract
Two approaches to the synthesis of oxygen-bridged tetrahydropyridones have been developed. In the first approach, substituted pyrido[4,3-g][1,3]oxazocines derivatives were prepared by diastereoselective one-pot reactions of substituted 7-azacoumarins with enolizable ketones and non-bulky primary amines. In the second one, 3-amido-7-azacoumarins were reacted with enolizable ketones in the presence of a base to form diastereomerically pure pyrido[4,3-g][1,3]oxazocines.
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- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
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