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Synlett 2015; 26(07): 921-926
DOI: 10.1055/s-0034-1380172
DOI: 10.1055/s-0034-1380172
letter
Total Synthesis of Two Pyrrole Spiroketal Alkaloids: Pollenopyrroside A and Capparisine B
Further Information
Publication History
Received: 25 November 2014
Accepted after revision: 12 January 2015
Publication Date:
10 February 2015 (online)
Abstract
Pollenopyrroside A and capparisine B, two diastereoisomers of pyrrole spiroketal alkaloids isolated from Brassica campestris pollen and Capparis spinosa, were synthesized by an improved microwave-assisted bishydroxymethylation of pyrrole and acid-catalyzed spirocyclization as key steps with total yields of 2.7 and 8.8%, respectively.
Key words
alkaloids - spiroketals - natural products - total synthesis - microwave-assisted reactionSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380172.
- Supporting Information
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