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Synthesis 2015; 47(11): 1557-1559
DOI: 10.1055/s-0034-1380511
DOI: 10.1055/s-0034-1380511
psp
Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one
Further Information
Publication History
Received: 23 February 2015
Accepted after revision: 07 March 2015
Publication Date:
02 April 2015 (online)
Abstract
A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde–tert-butanol mixture.
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