Simplifying Complex Scaffold Synthesis: Knoevenagel Adduct Allyl Anions as Easily Generated Multifunctional Reagents

Abstract

Knoevenagel adduct allyl anions are easily generated and can serve as platforms for formal 1,3-difunctionalization. Summarized herein are a variety of reaction pathways that can be harnessed for multistep synthesis with emphasis on carbocycle synthesis.

1 Introduction

2 Formal 1,3-Difunctionalization Reactivity Modes: An Overview

3 γ-Alkylation/Deconjugative α-Alkylation

4 Deconjugative α-Alkylation/Pairing Sequences

5 Deconjugative α-Alkylation/Allylic Substitution

6 Deconjugative α-Alkylation/Allylic Transposition/Deconjugative α-Alkylation

7 Future Directions

8 Conclusions

Key words

Knoevenagel adducts - allyl anions - deconjugative α-alkyl­ation - 1,3-difunctionalization - conjunctive reagents

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